Lead candidate

STC 1010 Our first candidate in metastatic colorectal cancer

An allogeneic first in class immunotherapy harnessing the patient immune system to fight immune tolerance and prevent cancer resistance
Phase I/II 1L mCRC study synopsis validated
Launch within 15 months (US, BEL, FR)

High unmet need

2nd cause of cancer mortality worldwide

608.000 Patients in 2029 WW

95% of patients treated by chemotherapies in 1L
(inducing tox & resistances)

Big Pharmas face a patent cliff For Standard of care : Pembrolizumab, Atezolizumab, Nivolumab, Ipilimumab (within 2028)

Our product

Our response

01. To meet the need in targeting treatment resistance

STC-1010 targets MSS and MSI-H population.

02. To meet the need in breaking immunue tolerance

STC-1010 has a robust and validated preclinical data pack showing:

  • Increase in overall survival

    in colorectal cold and hot mice model

  • Increase in CD8+ tumor infiltration

    in several model

  • Efficacy in anti-pd1 resistant

    mice model

03. To meet the need for an accessible approach

An OFF-THE-SHELF technology allowing control of both time and cost of the manufacturing process.

Stc1010, the missing link ? A biological rational

Adapted from C. Cremolini ESMO 2021 Schema Brenus pharma steps

Exemple of treatments with a biological rational to combine with STC 1010

  • Step 1

    GM-CSF low dose: Recruits APC at injection point and mature DCs.

  • Step 2

    Checkpoint inhibitors, ADC TLR Promotes T cell priming and activation

  • Step 3

    Chemokyne cytokine TLR : Increase trafficking of T cell

  • Step 4

    Bevacizumab Facilitates infiltration of CD8+ lymphocytes into tumors

  • Step 5

    5FU, Bevacizumab and Cyclophosphamide low dose, radiotherapy. Decrease the activity of immunosuppressive cells (Tregs and MDSCs)

  • Step 6

    Checkpoint inhibitors, ADC, BiSpecific mAb, TLR restores the anticancer immunity

At brenus, we aim to change a paradigm in Oncology